Allogeneic transfusions (someone else’s blood) can result in multiple inflammatory and immune reactions (acute or delayed hemolytic reactions).

Thus, the more is the blood units transfused, the higher is the antigens load (foreign body) injected into the patient’s circulation. Hence, on one side we have hemolytic reactions and on the other, the most critical, the immunomodulation.

Immunomodulators are substances that act at the immune system giving increased organic response against certain microorganisms, including viruses, bacteria and protozoa, through the production of interferon and its inducers.

Therefore, before an infection, this immune response is vital for the patient. This situation can worsen greatly in the presence of a blood transfusion, because the immune system (immunomodulators) will have now to act not only against the infectious agent, but also against a new hemotoxin (a substance that has direct or indirect harmful effect on the human body), in this case the allogeneic blood. This partly explains the several deleterious complications associated to blood transfusions.

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